Low Grade Inflammation and ECG Left Ventricular Hypertrophy in Urban African Males: The SABPA Study

作者：van der Walt Carel; Malan Leone^*; Uys Aletta S; Malan Nicolaas T

来源：Heart Lung and Circulation, 2013, 22(11): 924-929.

DOI：10.1016/j.hlc.2013.03.075

• Inflammation
• Blood pressure
• Left ventricular hypertrophy
• Ethnicity

Background: Hypertension and vascular hyperresponsiveness have been associated with structural wall abnormalities in black Africans. Whether low grade inflammation would have an additive effect is uncertain. Therefore, a novel investigation aimed to assess whether inflammation and pressure overload would have an additive association with ECG left ventricular hypertrophy (LVH).
Methods: We included 75 African and 87 Caucasian males. Ambulatory blood pressure monitoring was done in the working week. A resting 12-lead ECG recording was used for the determination of LVH with the Cornell product formula. Fasting blood samples were obtained for high sensitivity C-reactive protein (hs-CRP) analyses after a controlled overnight stay. Men were stratified into low (<= 3 mg/L) and high (>3 mg/L) hs-CRP groups.
Results: African men revealed higher ambulatory blood pressure levels compared to Caucasian men independent of hs-CRP levels after adjustment for age, physical activity, cotinine, log gamma-GT and body surface area. In forward stepwise linear regression analyses, SBP was positively associated with ECG LVH in all Africans. Considering low grade inflammatory status (>3 mg/L hs-CRP), SBP [Adj R-2 = 0.49 (beta = 0.99, 0.45, 1.44), p <= 0.011 and pulse pressure [Adj R-2 = 0.61 (beta = 0.0.34, 0.88), p <= 0.011 respectively, predicted ECG LVH in African but not in Caucasian men.
Conclusions: Hyperdynamic blood pressure and inflammation acted in tandem as possible promoting factors to structural wall abnormalities in African men.

• 出版日期2013-11
• 单位西北大学