科研之友
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摘要
National Cancer Center has reported that the male (5.2%) suffered from colorectal cancer (CRC) and the female is 4.8%, it is the second leading mortality of tumor. So far, few previous studies evaluated association between RTEL1 and CRC risk in a Chinese Han population. We conducted a case-control study including 247 CRC cases and 300 controls. Fourteen SNPs were selected from previous genome-wide association studies and genotyped using Sequenom MassARRAY technology. Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusting for age and gender. Using SPSS17.0 software and Microsoft Excel analyzed all the data. Dominant model (AA+AB vs. BB), Recessive model (BB vs. AB+AA), and Allele model (B vs. A) were used to evaluated the CRC risk. The rs2297441 in RTEL1 may increase odds of developing CRC (OR=1.26, 95% CI=0.100-1.630, P=0.049) and the SNP was related to increase the CRC risk in a recessive model (OR=1.96, 95% CI=1.109-3.456, P=0.020). After adjusted by age and gender, the results showed that rs2297441 in the RTEL1 increased 1.99-fold CRC risk (OR=1.99, 95% CI=1.115-3.563, P=0.020) in a recessive model. RTEL1 variant rs2297441 may be a potentially valuable marker for CRC patients.
