Detection of progressive macular thickness loss using optical coherence tomography in glaucoma suspect and glaucomatous eyes

作者：Niles P I; Greenfield D S; Sehi M^*; Bhardwaj N; Iverson S M; Chung Y S

来源：Eye, 2012, 26(7): 983-991.

DOI：10.1038/eye.2012.76

• glaucoma
• macular thickness
• imaging
• progression

Aims To examine the rate of macular thickness loss using time-domain optical coherence tomography (OCT) in functionally progressing versus non-progressing eyes, determined by standard automated perimetry (SAP). %26lt;br%26gt;Methods Glaucoma suspects (GS) and glaucomatous (G) eyes underwent SAP and OCT imaging every 6 months. Functional progression was determined using pointwise linear regression, defined as 2 contiguous locations losing %26gt;= 1.0 dB/year at P%26lt;1.0% in the same hemifield. The annual rate of macular thickness loss was calculated from inner and outer regions of the macular map. %26lt;br%26gt;Results 72 eyes (43 GS and 29G) with %26gt;= 30 months of follow-up were enroled. Fourteen eyes demonstrated SAP progression. The annual rate of macular thickness loss (mu m/year) in progressing eyes was faster (all P%26lt;0.05) than non-progressing eyes in temporal outer (-1.90 +/- 2.97 vs 0.33 +/- 2.77), nasal inner (-1.70 +/- 2.66 vs 0.14 +/- 2.76), superior inner (-2.15 +/- 4.57 vs 0.51 +/- 2.99), temporal inner quadrants (-2.58 +/- 5.05 vs -0.38 +/- 2.34), and the average of inner macular quadrants (-1.84 +/- 2.90 vs 0.03 +/- 2.10). The rate of loss in the nasal inner (P = 0.02) and temporal outer (P = 0.02) macular regions was associated with optic disc haemorrhage. %26lt;br%26gt;Conclusions Eyes with SAP progression have significantly greater rates of macular thickness loss consistent with glaucomatous retinal ganglion cell atrophy, as compared with non-progressing eyes. Eye (2012) 26, 983-991; doi:10.1038/eye.2012.76; published online 11 May 2012

• 出版日期2012-7