Melatonin injected into rat efficiently synchronizes the rhythm of protein synthesis in primary hepatocyte cultures isolated from this rat

作者：Brodsky V Ya^*; Rapoport S I; Dubovaya T K; Zvezdina N D; Fateeva V I; Malchenko L A

来源：Russian Journal of Developmental Biology, 2010, 41(2): 77-81.

DOI：10.1134/S1062360410020037

• intercellular interactions
• melatonin
• ultradian biorhythms
• protein synthesis

Melatonin injected intraperitoneally into rat synchronizes the ultradian rhythm of protein synthesis after 100 min in primary hepatocyte cultures isolated from this rat, which are studied after 1 or 2 days. The effective synchronization concentrations of melatonin-0.01-0.02 mu g per kg of rat weight-are three orders lower than melatonin doses used in clinical practice in human treatment.

• 出版日期2010-3