Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population

作者：Yucel Yavuz; Coskun Salih^*; Cengiz Beyhan; Ozdemir Hasan H; Uzar Ertugrul; Cim Abdullah; Camkurt M Akif; Aluclu M Ufuk

来源：Clinical Psychopharmacology and Neuroscience, 2016, 14(3): 250-255.

DOI：10.9758/cpn.2016.14.3.250

• Migraine disorders
• Single nucleotide polymorphism
• Receptor, serotonin, 5-HT2C
• Genetic association studies
• Headache

Objective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5 HT) and their respective receptors have been implicated in the patogenesis.
Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.
Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.
Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.

• 出版日期2016-8