An outbreak of acute hepatitis A among young adult men: clinical features and HIV coinfection rate from a large teaching hospital in Rome, Italy

作者：Ciccullo A^*; Gagliardini R; Baldin G; Borghetti A; Moschese D; Emiliozzi A; Lombardi F; Ricci R; Speziale D; Pallavicini F; Di Giambenedetto S

来源：HIV Medicine, 2018, 19(6): 369-375.

DOI：10.1111/hiv.12597

• hepatitis A
• HIV
• men who have sex with men
• outbreak

ObjectivesItaly is a low-incidence region for hepatitis A; however, during the last 2years an increase in the incidence of hepatitis A virus (HAV) infection was reported in Europe. The aim of this study was to describe this recent outbreak.
MethodsWe retrospectively analysed all cases of acute hepatitis A diagnosed at our laboratory between January 2010 and June 2017. We evaluated the following variables at the time of diagnosis: sex, age, nationality, glutamic oxaloacetic transaminase (GOT/AST), glutamic pyruvic transaminase (GPT/ALT), bilirubin concentration, international normalized ratio (INR) and the presence or absence of anti-HIV-1/2 antibodies. Hospitalization was also considered. We analysed these parameters using the (2) test and Mann-Whitney U-test.
ResultsA total of 225 cases were analysed; 82.7% were in male patients, 94.2% were in Italians and the median age of the patients was 36.4 years. At diagnosis, the median GOT value was 306 U/L, the median GPT was 1389 U/L, and the median total bilirubin value was 5.88mg/dL. Hospitalization was required for 142 patients, with a median duration of hospital stay of 8.5days. In 2016-2017 we registered 141 cases, with a higher prevalence of male patients, higher GPT values and a higher prevalence of patients aged 20-39years compared with older (2010-2015) cases. Homosexual intercourse was reported as the HAV risk factor in 70.2% of patients. HIV serology was available for 120 patients: 24 were HIV-positive, four of whom represented new diagnoses. HIV-positive patients showed lower bilirubin and GPT values and fewer hospitalizations than HIV-negative patients.
ConclusionsIn 2016-2017, we saw a rise in the number of hepatitis A cases, with a higher prevalence of adult male patients. No significant differences regarding the prevalence of HIV coinfection emerged.

• 出版日期2018-7