摘要
GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. There had been genomewide analysis discovering polymorphism rs2373115 correlated with AD and in this study we performed an association analysis on this polymorphism in 107:100 Mongolian Alzheimer patients and controls in order to discover whether this correlation can be replicated in Chinese minority group. The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.
- 出版日期2010-8-9
- 单位内蒙古医科大学; 中国医学科学院北京协和医院; 哈尔滨医科大学; 国家卫生计生委科学技术研究所