A utilizaˋˋo do tubo de 芍cido poliglic車lico e FK506 na regeneraˋˋo de nervos perif谷ricos

作者：Costa; Marcio Paulino; Cunha; Armando dos Santos; Silva; Ciro Ferreira da; Barros Filho; Tarcisio E P; Ferreira; Marcus Castro

来源：Acta Ortop%26eacute;dica Brasileira, 2006.

DOI：10.1590/S1413-78522006000100005

• peripheral nerves [surgery]
• nerve regeneration
• polyglycoic acid [therapeutic use]
• immunosuppressive agents [therapeutic use].

extensive losses of neural tissue preclude the repair performed by means of primary anastomosis. in those cases, nerve autograft is considered as the treatment of choice. the synthetic tube constituted by polyglycoic acid is an option for nerve graft. the fk506 is an immunosuppressive agent, which increases the neural regeneration rates in vivo and in vitro. the purpose of this study was to compare, in rats, the degree of neural regeneration, by using histological analysis, a count of the number of regenerated myelinated axons, and a functional analysis, obtained by interposing the autogenous graft (group a), polyglycoic acid tube (group b) and a combination of polyglycoic acid tube with fk506 (group c) in 5-cm defects of the sciatic nerve. neuroma formation was observed only in group a. groups b and c presented similar histological patterns. the quantitative analysis of the number of regenerated myelinated axons has determined that: 1) group b presented, in average, a lower number when compared to the other groups; 2) there was no significant difference between control group a and group c. for functional recovery, there was no statistically significant change between the three groups, despite the qualitative and quantitative histological differences seen.

• 出版日期2006