Arterial Stiffness and Wave Reflections in Relation to Plasma Advanced Glycation End Products in a Chinese Population

作者：Huang, Qi-Fang; Sheng, Chang-Sheng; Liu, Ming; Li, Fa-Hong; Li, Yan; Wang, Ji-Guang^*

来源：American Journal of Hypertension, 2013, 26(6): 754-761.

DOI：10.1093/ajh/hpt014

• advanced glycation end products
• arterial stiffness
• blood pressure
• Chinese
• hypertension
• population
• wave reflections

BACKGROUND @@@ Accumulation of advanced glycation end products (AGEs) in the human body might engender arterial stiffening. We investigated the relationship of plasma AGE concentration with arterial stiffness and wave reflections in a Chinese population. @@@ METHODS @@@ The study subjects were recruited from a newly established residential area in the suburb of Shanghai in 2009. Using the SphygmoCor system, we measured carotid-femoral pulse wave velocity (cfPWV) and central augmentation indices (cAI) and peripheral augmentation indices (pAI). Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. @@@ RESULTS @@@ The 1,051 study participants (mean age = 55.1 +/- 13.1 years) included 663 (63.1%) women, 390 (37.1%) hypertensive patients, and 90 (8.6%) diabetic or prediabetic subjects. Plasma AGE concentration was higher in men than women (5.62 vs. 5.07 mu g/ml; P = 0.02) and with older age (r = 0.13 in both sexes; P <= 0.01) and higher serum total/high-density lipoprotein cholesterol ratio (r = 0.20 in men and r = 0.15 in women; P < 0.0001). In multiple regression analyses, plasma AGE concentration was significantly associated with cAI and pAI (1.9% and 4.0% increase per 10-time increase in plasma AGE concentration, respectively; P <= 0.02) but not with cfPWV (P = 0.62). However, there was significant (P = 0.001) interaction between plasma AGE concentration and age in relation to cfPWV. Only in subjects aged >= 70 years, cfPWV increased with higher levels of plasma AGE concentration (bottom vs. top quintile distributions = 8.10 vs. 8.90 m/s; P = 0.02). @@@ CONCLUSIONS @@@ AGEs accumulate with aging and high cholesterol and are associated with arterial wave reflections and, in an age-dependent manner, with arterial stiffness.

• 出版日期2013-6
• 单位上海市闵行区中心医院; 上海交通大学