An In Vitro Experimental Approach to Study Magnetically Targeted Release of Methotrexate From Superparamagnetic Starch Nanocarriers

作者：Likhitkar Sweta; Bajpai A K^*

来源：International Journal of Polymeric Materials and Polymeric Biomaterials, 2014, 63(18): 941-950.

DOI：10.1080/00914037.2014.886232

• Drug delivery
• methotrexate
• nanoparticles
• release

In the field of drug delivery, magnetic nanoparticles have great potential to modernize anticancer therapy. In the present study iron oxides containing superparamagnetic starch nanoparticles were prepared by emulsion crosslinking method. The anticancer drug methotrexate was used for loading onto the magnetic starch nanoparticles and released drug was spectrophotometrically monitored at physiological pH (7.4) under application of a modulating magnetic field. The spectroscopic techniques such as FTIR, TEM, X-ray diffraction, and vibrating sample magnetometer (VSEM) studies were used to characterize the magnetic starch nanocarriers. The influence of various experimental parameters such as pH and temperature of the release media, percent drug loading, chemical compositions of nanocarriers, and applied magnetic field were investigated on the drug release profiles of synthesized magnetic starch nanoparticles. The nanoparticles were also evaluated for cytotoxicity and in vitro blood compatibility.

• 出版日期2014