Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis

作者：Chen Jih Jung^*; Hung Hsin Chih; Sung Ping Jyun; Chen Ih Sheng; Kuo Wen Lung

来源：Phytochemistry, 2011, 72(6): 523-532.

DOI：10.1016/j.phytochem.2010.12.015

• Illigera luzonensis
• Hernandiaceae
• Structure elucidation
• Alkaloid
• Aporphine
• Lignan
• Cytotoxicity

Six aporphine alkaloids, (+)-(S)-N-butyrylcaaverine (1), (+)-(S)-N-propionylcaaverine (2), (+)-(S)-N-acetylcaaverine (3), (+)-(6aR,7R)-N-butyrylnorushinsunine (4), (+)-(6aR,7R,E)-N-(but-2-enoyl)norushinsunine (5), and N-formyldehydrocaaverine (6) were isolated from the roots of Illigera luzonensis, together with 16 known compounds. Their structures were determined through spectroscopic and MS analyses. Among the isolates, (-)-deoxypodophyllotoxin (13) was the most cytotoxic, with IC(50) values of 0.0057, 0.0067, 0.00004, and 0.0035 mu g/mL, respectively, against DLD-1, CCRF-CEM, HL-60, and IMR-32 cell lines. In addition, (-)-yatein (12) exhibited cytotoxic effects, with IC(50) values of 0.81, 0.20, and 0.59 mu g/ml, respectively, against DLD-1, CCRF-CEM, and HL-60 cell lines.

• 出版日期2011-4