科研之友
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摘要
Purpose: The present study was conducted to evaluate the effect of platelet-rich plasma (PRP) on new bone formation and remodeling after grafting of the maxillary sinus with an algae-derived hydroxyapatite AlgOss/C Graft/Algipore. %26lt;br%26gt;Materials and Methods: Fourteen consecutive patients with severely atrophic maxillae underwent uni- or bilateral grafting of the maxillary sinus with a mixture of collected bone, algae-derived hydroxyapatite AlgOss/C Graft/Algipore (ratio 1: 10), and a combined addition of PRP and thrombin (Tissucol Kit; Baxter, Vienna, Austria) to allow for fast clotting. After an average healing period of 7.1 months bone samples were retrieved. Patients from a former consecutive series treated without PRP served as control group. Statistical analysis was done by Welch 2-sample t test and mixed linear model testing. %26lt;br%26gt;Results: In the coronal specimen portions, mean values for newly formed bone area, biomaterial area and marrow space of 32.2% +/- 10.4%, 20.1% +/- 13.0%, and 47.7% +/- 8.5% were found with PRP, respectively. In the control group the corresponding values were 27.6% +/- 13.4%, 20.3% +/- 12.9%, and 52.1% +/- 9.3%. In the apical specimen portions in the PRP group, the newly formed bone area, biomaterial area, and marrow space was 25.7% +/- 15.0%, 23.4% +/- 14.9%, and 50.9% +/- 12.5%, respectively. The corresponding values in the control group were 17.0% +/- 8.6%, 34.5% +/- 11.2%, and 48.5% +/- 8.5%. %26lt;br%26gt;Conclusions: Statistical evaluation of the samples proved significantly better overall resorption of algae-derived hydroxyapatite AlgOss/C Graft/Algipore and increased new bone formation when PRP was used, especially in the apical region.
- 出版日期2012-3
