Potential relationship and clinical significance of miRNAs and Th17 cytokines in patients with multiple myeloma

作者：Li, Yanjie; Li, Depeng; Yan, Zhiling; Qi, Kunming; Chen, Lili; Zhang, Zhiyao; Fan, Guoqin; Li, Hujun; Xu, Kailin; Li, Zhenyu^*

来源：Leukemia Research, 2014, 38(9): 1130-1135.

DOI：10.1016/j.leukres.2014.07.005

• miRNAs
• Th17 cytokines
• Multiple myeloma

We evaluated the potential relationship between miRNAs and Th17 cytokines in multiple myeloma (MM) patients. Twenty-seven newly diagnosed myeloma patients and eight normal donors were studied. We determined that the relative expression levels of miR-15a116, miR-34a, miR-194 in MM patients were significantly lower than those in the healthy controls with exception for miR-181a/b, which showed significantly higher in MM patients (P < 0.05). In contrast, the levels of IL-17, IL-21 and IL-27 were up-regulated in MM patients compared to healthy controls while IL-22 was down-regulated (P < 0.05). The expression patterns of them were differentially present in various groups according to the International Staging System (ISS) criteria. Up-regulated IL-17, IL-21 and IL-27 may potentially down-regulate the expression of several miRNAs in MM patients. Establishment of the relationship may be useful for understanding the pathogenesis of MM and for clinical diagnosis of the disease.

• 出版日期2014-9
• 单位徐州医科大学