Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells

作者：Kang SS; Lee JY; Choi YK; Kim GS; Han BH^*

来源：Bioorganic & Medicinal Chemistry Letters, 2004, 14(9): 2261-2264.

DOI：10.1016/j.bmcl.2004.02.003

Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.

• 出版日期2004-5-3