Method for the Efficient Synthesis of Highly-Substituted Oxetan- and Azetidin-, Dihydrofuran- and Pyrrolidin-3-ones and Its Application to the Synthesis of (+/-)Pseudodeflectusin

作者：Maegawa Tomohiro; Otake Kazuki; Hirosawa Keiichi; Goto Akihiro; Fujioka Hiromichi^*

来源：Organic Letters, 2012, 14(18): 4798-4801.

DOI：10.1021/ol302096j

Highly substituted four- and five-membered heterocycles were prepared starting with O,P- and N,P-acetals by using a one-pot method involving base induced cyclization and a Horner-Wadsworth-Emmons (HWE) olefination reaction. Divergent synthesis of various heterocycles was achieved by using this method and transformations of the alkenyl group in the products of these processes were exemplified. Finally, a short and efficient synthesis of (+/-)-pseudodeflectusin based on the new methodology was achieved.

• 出版日期2012-9-21