Aiolos: An ungrateful member of the Ikaros family

作者:Kioussis Dimitris*
来源:Immunity, 2007, 26(3): 275-277.
DOI:10.1016/j.immuni.2007.03.003

摘要

Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda 5 and eliminates the very structure that signaled its appearance.