科研之友
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摘要
A facile synthetic method for preparing 3-amino-2-silylaryl triflates via regioselective silylamination of 3(triflyloxy)arynes with N-silylamines is described. Fluoride mediated generation of 3-aminobenzyne from 3-amino-2-silylphenyl triflate, easily prepared by this method, in the presence of various arynophiles efficiently afforded diverse aniline derivatives, including a 5-aminocoumarin derivative, demonstrating the utility of aryne relay approach.
- 出版日期2016-12-2
