The Preparation of Trisubstituted Alkenyl Nucleoside Phosphonates under Ultrasound-Assisted Olefin Cross-Metathesis

作者:Sari Ozkan; Hamada Manabu; Roy Vincent; Nolan Steven P; Agrofoglio Luigi A*
来源:Organic Letters, 2013, 15(17): 4390-4393.
DOI:10.1021/ol401922r

摘要

Intermolecular ultrasound-assisted olefin cross-metathesis is reported. This approach allows an easy access to challenging trisubstituted alkenyl nucleoside phosphonates. Regioselective chemoenzymatic deacetylation and Mitsunobu coupling are also described.

  • 出版日期2013-9-6