Nanomechanical testing technique for millimeter-sized and smaller molecular crystals

作者：Maughan Michael R; Carvajal M Teresa; Bahr David F^*

来源：International Journal of Pharmaceutics, 2015, 486(1-2): 324-330.

DOI：10.1016/j.ijpharm.2015.03.062

• Griseofulvin
• Nanoindentation
• Molecular crystals
• Elastic-plastic indentation
• Batch variation

Large crystals are used as a control for the development of a mounting and nanoindentation testing technique for millimeter-sized and smaller molecular crystals. Indentation techniques causing either only elastic or elastic-plastic deformation produce similar results in assessing elastic modulus, however, the elastic indents are susceptible to surface angle and roughness effects necessitating larger sample sizes for similar confidence bounds. Elastic-plastic indentations give the most accurate results and could be used to determine the different elastic constants for anisotropic materials by indenting different crystal faces, but not by rotating the indenter about its axis and indenting the same face in a different location. The hardness of small and large crystals is similar, suggesting that defect content probed in this study is similar, and that small crystals can be compared directly to larger ones. The Young's modulus and hardness of the model test material, griseofulvin, are given for the first time to be 11.5 GPa and 0.4 GPa respectively.

• 出版日期2015-5-30