Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction - Result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial

作者：Ripa RS; Jorgensen E; Wang YZ; Thune JJ; Nilsson JC; Sondergaard L; Johnsen HE; Kober L; Grande P; Kastrup J^*

来源：Circulation, 2006, 113(16): 1983-1992.

DOI：10.1161/CIRCULATIONAHA.105.610469

• angiogenesis
• heart failure
• magnetic resonance imaging
• myocardial infarction
• stem cells

Background: Phase 1 clinical trials of granulocyte-colony stimulating factor (G-CSF) treatment after myocardial infarction have indicated that G-CSF treatment is safe and may improve left ventricular function. This randomized, double-blind, placebo-controlled trial aimed to assess the efficacy of subcutaneous G-CSF injections on left ventricular function in patients with ST-elevation myocardial infarction.
Methods and Results: Seventy-eight patients (62 men; average age, 56 years) with ST-elevation myocardial infarction were included after successful primary percutaneous coronary stent intervention < 12 hours after symptom onset. Patients were randomized to double-blind treatment with G-CSF (10 mu g/kg of body weight) or placebo for 6 days. The primary end point was change in systolic wall thickening from baseline to 6 months determined by cardiac magnetic resonance imaging (MRI). An independent core laboratory analyzed all MRI examinations. Systolic wall thickening improved 17% in the infarct area in the G-CSF group and 17% in the placebo group (P = 1.0). Comparable results were found in infarct border and noninfarcted myocardium. Left ventricular ejection fraction improved similarly in the 2 groups measured by both MRI (8.5 versus 8.0; P = 0.9) and echocardiography (5.7 versus 3.7; P = 0.7). The risk of severe clinical adverse events was not increased by G-CSF. In addition, in-stent late lumen loss and target vessel revascularization rate in the follow-up period were similar in the 2 groups.
Conclusions: Bone marrow stem cell mobilization with subcutaneous G-CSF is safe but did not lead to further improvement in ventricular function after acute myocardial infarction compared with the recovery observed in the placebo group.

• 出版日期2006-4-25