Genetics of Asthma Susceptibility and Severity

作者：Slager Rebecca E; Hawkins Gregory A; Li Xingnan; Postma Dirkje S; Meyers Deborah A; Bleecker Eugene R^*

来源：Clinics in Chest Medicine, 2012, 33(3): 431-+.

DOI：10.1016/j.ccm.2012.05.005

• Asthma
• Genetics
• Susceptibility
• Severity
• Personalized medicine
• Therapy
• Lung function

This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

• 出版日期2012-9