A Method of Effectively Improved alpha-Mangostin Bioavailability

作者：Zhao, Yan^*; Tang, Guosheng; Tang, Qiang; Zhang, Jing; Hou, Yingying; Cai, Enbo; Liu, Shuangli; Lei, Daihong; Zhang, Lianxue^*; Wang, Shijie

来源：European Journal of Drug Metabolism and Pharmacokinetics, 2016, 41(5): 605-613.

DOI：10.1007/s13318-015-0283-4

• GARCINIA-MANGOSTANA
• ANTIINFLAMMATORY ACTIVITY
• TISSUE DISTRIBUTION
• FRUIT EXTRACT
• CANCER CELLS
• XANTHONES
• PHARMACOKINETICS
• RATS
• HULL
• PROLIFERATION

alpha-Mangostin, a major xanthone isolated from the pericarp of Garcinia mangostana, exhibits anti-inflammatory and antitumor effects. Its absolute bioavailability is low, with minimal oral absorption. In this article, a soft capsule, with vegetable oil as the dispersion matrix, was prepared to improve the bioavailability of alpha-mangostin. Its pharmacokinetics and tissue distribution were determined in rats. An HPLC assay was established to determine the concentration of alpha-mangostin in biological samples. The validated method was used successfully to support pharmacokinetic and tissue distribution studies of alpha-mangostin in rats after intravenous (i.v.) and oral administration. The pharmacokinetic study found the absolute bioavailabilities of low, medium and high doses were 61.1, 51.5 and 42.5 %, respectively, indicating that the absolute bioavailability was effectively improved.

• 出版日期2016-10
• 单位吉林农业科技学院; 吉林农业大学