Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones

作者：Miyamae Naomu; Watanabe Naruhisa; Moritaka Maya; Nakano Keiji; Ichikawa Yoshiyasu; Kotsuki Hiyoshizo^*

来源：Organic and Biomolecular Chemistry, 2014, 12(31): 5847-5855.

DOI：10.1039/c4ob00733f

A highly diastereosetective and enantioselective method for the asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones using the Michael addition reaction of malonates under catalysis with the primary amine-thiourea conjugate catalyst and PPY at high pressure was developed.

• 出版日期2014-8-21