Low protein provision during the first year of life, but not during foetal life, affects metabolic traits, organ mass development and growth in male mink (Neovison vison)

作者：Vesterdorf K; Blache D; Harrison A; Matthiesen C F; Tauson A H^*

来源：Journal of Animal Physiology and Animal Nutrition, 2014, 98(2): 357-372.

DOI：10.1111/jpn.12108

• post-weaning malnutrition
• hepatic lipidosis
• nitrogen metabolism
• body composition
• foetal programming
• plasma hormones

Low protein provision in utero and post-partum may induce metabolic disorders in adulthood. Studies in mink have mainly focused on short-term consequences of low protein provision in utero whereas the long-term responses to low protein (LP) provision in metabolically programmed mink are unknown. We investigated whether low protein provision in utero affects the long-term response to adequate (AP) or LP provision after weaning in male mink. Eighty-six male mink were exposed to low (19% of ME from CP; crude protein) or adequate (31% of ME from CP) protein provision in utero, and to LP (similar to 20% of ME from CP) or AP (30-42% of ME from CP) provision post-weaning. Being metabolically programmed by low protein provision in utero did not affect the response to post-weaning diets. Dietary protein content in the LP feed after weaning was below requirements; evidenced by lower nitrogen retention (p<0.001) preventing LP mink from attaining their growth potential (p<0.02). LP mink had a lower liver, pancreas and kidney weight (p<0.05) as well as lower plasma IGF-1 concentrations at 8 and 25 (p<0.05) weeks, and a higher incidence of hepatic lipidosis at 25weeks (p<0.05). Furthermore, LP mink had a higher body fat (p<0.05) and lower body CP content (p<0.05) at 50weeks of age. It is concluded that some effects of low protein provision in utero can be alleviated by an adequate nutrient supply post-partum. However, long-term exposure to low protein provision in mink reduces their growth potential and induces transient hepatic lipidosis and modified body composition.

• 出版日期2014-4