Noncontrast myocardial T-1 mapping using cardiovascular magnetic resonance for iron overload

作者：Sado Daniel M; Maestrini Viviana; Piechnik Stefan K; Banypersad Sanjay M; White Steven K; Flett Andrew S; Robson Matthew D; Neubauer Stefan; Ariti Cono; Arai Andrew; Kellman Peter; Yamamura Jin; Schoennagel Bjoern P; Shah Farrukh; Davis Bernard; Trompeter Sara; Walker Malcolm; Porter John; Moon James C^*

来源：Journal of Magnetic Resonance Imaging, 2015, 41(6): 1505-1511.

DOI：10.1002/jmri.24727

• MRI
• iron
• T-1

PurposeTo explore the use and reproducibility of magnetic resonance-derived myocardial T-1 mapping in patients with iron overload.
Materials and MethodsThe research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T-1 mapping used the shortened modified Look-Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T-2* was performed using a commercially available sequence. The analysis of the T-2* interstudy reproducibility data was performed by two different research groups using two different methods.
ResultsMyocardial T-1 was lower in patients than healthy volunteers (836138 msec vs. 968 +/- 32 msec, P<0.0001). Myocardial T-1 correlated with T-2* (R=0.79, P<0.0001). No patient with low T-2* had normal T-1, but 32% (n=28) of cases characterized by a normal T-2* had low myocardial T-1. Interstudy reproducibility of either T-1 sequence was significantly better than T-2*, with the results suggesting that the use of T-1 in clinical trials could decrease potential sample sizes by 7-fold.
ConclusionMyocardial T-1 mapping is an alternative method for cardiac iron quantification. T-1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T-1 has potential implications for clinical trial design and therapeutic monitoring. J. Magn. Reson. Imaging 2015;41:1505-1511.

• 出版日期2015-6