科研之友
微信
新浪微博
Facebook
分享链接
摘要
The adenosine A(2A) receptor is a G-protein-coupled receptor (GPCR) that has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Herein we describe adenosine A(2A) receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the most relevant series of adenosine A(2A) agonists and antagonists. This review also provides an update of the A(2A) ligands that are undergoing or have undergone clinical studies, including the two currently marketed agonists adenosine and regadenoson.
- 出版日期2014-5-8
