Efficacy of Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema After Vitrectomy

作者：Watanabe Akira^*; Tsuzuki Akane; Arai Kota; Gekka Tamaki; Kohzaki Kenichi; Tsuneoka Hiroshi

来源：Journal of Ocular Pharmacology and Therapeutics, 2016, 32(1): 38-43.

DOI：10.1089/jop.2015.0045

Purpose: To compare the efficacy of intravitreal injection of triamcinolone acetonide (IVTA) for diabetic macular edema (DME) in vitrectomized eyes with DME without vitrectomy eyes. Methods: This retrospective comparative study evaluated the efficacy of IVTA treatment of DME in 26 consecutive eyes (23 patients). Changes in mean best-corrected visual acuity (VA) and mean central retinal thickness (CRT) were retrospectively evaluated before IVTA and during the 6-month period after IVTA. Results: Subjects were divided into 2 groups: 13 consecutive eyes (11 patients) with proliferative diabetic retinopathy or DME that underwent vitrectomy (vitrectomized group), and 13 consecutive eyes (12 patients) with DME who received IVTA, but did not undergo vitrectomy (nonvitrectomized group). In the vitrectomized group, there was a significantly decreased CRT for up to 4 months as compared to the thicknesses before IVTA. In the nonvitrectomized group, there was a significantly decreased CRT for up to 5 months after IVTA. In both groups, there was significant improvement in the VA for up to 4 months after IVTA. Conclusion: IVTA may represent a valid treatment option for DME, even in vitrectomized eyes.

• 出版日期2016-1-1