Hydroxychloroquine is a good second-line treatment for adults with immune thrombocytopenia and positive antinuclear antibodies

作者：Khellaf Mehdi^*; Chabrol Amelie; Mahevas Matthieu; Roudot Thoraval Francoise; Limal Nicolas; Languille Laetitia; Bierling Philippe; Michel Marc; Godeau Bertrand

来源：American Journal of Hematology, 2014, 89(2): 194-198.

DOI：10.1002/ajh.23609

Treatment of patients with lupus-associated thrombocytopenia (SLE-ITP) is not standardized. We report data on efficacy and safety of hydroxychloroquine (HCQ) in this setting and in ITP patients with positive antinuclear antibodies (ANA) without definite SLE. Inclusion criteria were: definite diagnosis of ITP with a platelet count (PLT) <50 x 10(9)/L, ANA 1/160 on Hep2 cells with or without a definite diagnosis of SLE, and no sustained response to at least one previous treatment-line and treatment with HCQ. Response criteria were Complete Response (CR) for PLT 100 x 10(9)/L and Response (R) for PLT 30 x 10(9)/L and at least twice the initial value. Forty patients (32 females) with a mean age of 35 +/- 17 years and PLT at ITP diagnosis of 14 +/- 13 x 10(9)/L were analyzed. Twelve (30%) patients had a SLE-ITP, 28 patients had only positive ANA. All the patients failed to respond to oral prednisone with a median of two treatment-lines (1-5) before HCQ which was initially given in combination with another ITP treatment in 36 patients. Overall response rate was 60% (24/40) including 18 lasting CR and six lasting R maintained with a median follow-up of 64 months (6-146), in of cases with only HCQ and no concomitant ITP treatment. The response rate (CR+R) was higher in the SLE group vs ANA-positive group (83% vs 50%, P<0.05). No patient stopped HCQ because of a side-effect. HCQ appears to be a safe and effective second line treatment for patients with SLE-ITP or ITP and high titer of ANA. This trial was registered at as # NCT01549184. Am. J. Hematol. 89:194-198, 2014.

• 出版日期2014-2