Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don

作者：Changwichit Kanokwan; Khorana Nantaka; Suwanborirux Khanit^*; Waranuch Neti; Limpeanchob Nanteetip; Wisuitiprot Wutichai; Suphrom Nungruthai; Ingkaninan Kornkanok

来源：Fitoterapia, 2011, 82(6): 798-804.

DOI：10.1016/j.fitote.2011.04.013

• Alstonia macrophylla
• AChE inhibitor
• BChE inhibitor
• Bisindole alkaloids
• Secoiridoid glycosides
• Prostate cancer cell

The ethanolic extract from stems of a Thai medicinal plant. Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF).

• 出版日期2011-9