Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

作者：Armstrong Nicola J; Mather Karen A; Thalamuthu Anbupalam; Wright Margaret J; Trollor Julian N; Ames David; Brodaty Henry; Schofield Peter R; Sachdev Perminder S; Kwok John B

来源：Epigenomics, 2017, 9(5): 689-700.

DOI：10.2217/epi-2016-0179

• acceleration
• age
• aging
• centenarians
• DNAmage
• epigenetic clock
• longevity

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

• 出版日期2017-5