The "good-cop bad-cop" TGF-beta role in breast cancer modulated by non-coding RNAs

作者：Gulei Diana; Mehterov Nikolay; Ling Hui; Stanta Giorgio; Braicu Cornelia^*; Berindan Neagoe Ioana^*

来源：Biochimica et Biophysica Acta-General Subjects, 2017, 1861(7): 1661-1675.

DOI：10.1016/j.bbagen.2017.04.007

• Breast cancer
• EMT
• TGF-beta
• miRNA
• lncRNA

Background: Lack of early diagnosis methods and the development of drug resistance are among the main reasons for increased mortality rates within breast cancer patients. These two aspects are governed by specific pro-carcinogenic modifications, where TGB beta-induced EMT is one of the leading actors. Endowment of the epithelial cells with mesenchymal characteristics allows them to migrate and invade secondary tissues in order to form malignant sites and also confers chemoresistance. TGE beta which role switches from the tumor suppressor cytokine to the oncogenic one favoring the tumor microenvironment regulates this process.
Scope of review: This review aims to comprehensively present the updated TGF beta-induced EMT in breast cancer, including the regulatory role of the non-coding RNAs with focus on the miR-200 family and newly discovered lncRNAs such as HOTAIRM1. Additionally, a new phenotype, P-EMT, also modulated by miR-200 and miR-34 families that form complex feedback loops with TGF beta, SNAIL and ZEB1/2 is presented under an updated form.
Major conclusions: The hallmarks of EMT are becoming increasingly associated with aggressive forms of breast cancer and low survival rates among patients. Considering that this phenotypical switch can trigger drug resistance, invasion and metastasis, inhibition of EMT could represent an important milestone in mammary cancer treatment.
General significance: The present review assembles the most recent data regarding TGF beta induced EMT, including the input of non-coding RNAs, contributing to the possible development of new targeted treatment strategies for cancer patients.

• 出版日期2017-7