Nickel(II)-Magnesium-Catalyzed Cross-Coupling of 1,1-Dibromo-1-alkenes with Diphenylphosphine Oxide: One-Pot Synthesis of (E)-1-Alkenylphosphine Oxides or Bisphosphine Oxides

作者：Liu Liu; Wang Yulei; Zeng Zhiping; Xu Pengxiang; Gao Yuxing^*; Yin Yingwu; Zhao Yufen

来源：Advanced Synthesis & Catalysis, 2013, 355(4): 659-666.

DOI：10.1002/adsc.201200853

• (E)-1-alkenylphosphine oxides
• bisphosphine oxides
• 1
• 1-dibromo-1-alkenes
• DFT calculations
• nickel(II)-magnesium catalysis

A novel nickel(II)-magnesium-mediated cross-coupling of diphenylphosphine oxide with a variety of 1,1-dibromo-1-alkenes has been developed, which provides a powerful and general methodology for the stereoselective synthesis of various (E)-1-alkenylphosphine oxides or bisphosphine oxides, with operational simplicity of the procedure, good to high yields and broad substrate applicability. Mechanistic studies reveal that the reaction might involve a Hirao reduction, cross-coupling and Michael addition.

• 出版日期2013-3
• 单位厦门大学