Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment

作者：Vigezzi Lucia; Bosquiazzo Veronica L; Kass Laura; Ramos Jorge G; Munoz de Toro Monica; Luque Enrique H^*

来源：Reproductive Toxicology, 2015, 52: 83-92.

DOI：10.1016/j.reprotox.2015.01.011

• Bisphenol A
• Rat
• Uterus
• Uterine glands
• Steroid receptors
• p63

We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50 mu g/kg/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and a-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the lumina] and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.

• 出版日期2015-4