A Facile One-Pot Metal-Free Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

作者：Jia, Qianfa; Yang, Gongming; Chen, Lei; Du, Zhiyun^*; Wei, Jia; Zhong, Yanqiong; Wang, Jian

来源：European Journal of Organic Chemistry, 2015, 2015(16): 3435-3440.

DOI：10.1002/ejoc.201500360

• Metal-free synthesis
• Triazoles
• Azides
• 1,3-Dipolar cycloaddition

A 1,3-dipolar cycloaddition reaction of commercially available aldehydes with azides and secondary amines through a one-pot strategy has been developed. This method furnishes 1,4-disubstituted 1,2,3-triazoles in good to excellent yields and high levels of regioselectivity.

• 出版日期2015-6
• 单位广东工业大学