Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

作者：Malnati Mauro S; Ugolotti Elisabetta; Monti Maria Cristina; De Battista Davide; Vanni Irene; Bordo Domenico; Sironi Francesca; Larghero Patrizia; Di Marco Eddi; Biswas Priscilla; Poli Guido; Vicenzi Elisa; Riva Agostino; Tarkowski Maciej; Tambussi Giuseppe; Nozza Silvia; Tripodi Gino; Marras Francesco; De Maria Andrea; Pistorio Angela; Biassoni Roberto^*

来源：Scientific Reports, 2017, 7(1): 42470.

DOI：10.1038/srep42470

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia.

• 出版日期2017-2-13