Glycan-functionalized graphene-FETs toward selective detection of human-infectious avian influenza virus

作者：Ono Takao; Oe Takeshi; Kanai Yasushi; Ikuta Takashi; Ohno Yasuhide; Maehashi Kenzo; Inoue Koichi; Watanabe Yohei; Nakakita Shin ichi; Suzuki Yasuo; Kawahara Toshio; Matsumoto Kazuhiko^*

来源：Japanese Journal of Applied Physics, 2017, 56(3): 030302.

DOI：10.7567/JJAP.56.030302

There are global concerns about threat of pandemic caused by the human-infectious avian influenza virus. To prevent the oncoming pandemic, it is crucial to analyze the viral affinity to human-type or avian-type sialoglycans with high sensitivity at high speed. Graphene-FET (G-FET) realizes such high-sensitive electrical detection of the targets, owing to graphene's high carrier mobility. In the present study, G-FET was functionalized using sialoglycans and employed for the selective detection of lectins from Sambucus sieboldiana and Maackia amurensis as alternatives of the human and avian influenza viruses. Glycan-functionalized G-FET selectively monitored the sialoglycan-specific binding reactions at subnanomolar sensitivity.

• 出版日期2017-3