A serious adverse event secondary to rapid intravenous levetiracetam injection in a dog

作者：Biddick Allison A^*; Bacek Lenore M; Taylor Amanda R

来源：Journal of Veterinary Emergency and Critical Care, 2018, 28(2): 157-162.

DOI：10.1111/vec.12693

• seizure
• status epilepticus
• levetiracetam
• anaphylaxis

ObjectiveTo describe a serious adverse event as a result of rapid intravenous injection of undiluted levetiracetam in a dog.
Case SummaryAn 8-year-old female spayed Chihuahua was evaluated for cluster seizures and tachypnea. The patient was administered an intravenous dose of undiluted levetiracetam (60 mg/kg) and immediately developed tachycardia, hyperglycemia, hypotension, and a dull mentation. The patient's blood pressure and mentation did not respond to intravenous fluid boluses but improved immediately after administration of epinephrine intravenously. The patient subsequently developed respiratory failure necessitating mechanical ventilation, prior to cardiac arrest. Necropsy examination noted a pulmonary inflammatory cell infiltrate, pulmonary edema, and interstitial pneumonia.
New or Unique Information ProvidedThis report documents a serious adverse event associated with intravenous levetiracetam administration to a dog.

• 出版日期2018-4