New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcRIIB (CD32B)

作者：Roghanian Ali^*; Stopforth Richard J; Dahal Lekh N; Cragg Mark S

来源：Journal of Leukocyte Biology, 2018, 103(6): 1077-1088.

DOI：10.1002/JLB.2MIR0917-354R

• Fc gamma receptor
• IgG
• immunotherapy
• B lymphocytes
• myeloid
• antibodies

The Fc gamma receptor IIB (FcRIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcRIIB are emerging. In particular, FcRIIB has been shown to perform unexpected activatory roles in both immune-signaling and monoclonal antibody (mAb) immunotherapy. Furthermore, although ITIM signaling is an integral part of FcRIIB regulatory activity, it is now clear that inhibition/activation of immune responses can occur independently of the ITIM. In light of these new findings, we present an overview of the established and noncanonical functions of FcRIIB and discuss how this knowledge might be exploited therapeutically.

• 出版日期2018-6
• 单位MIT