Cooperation of Biological and Mechanical Signals in Cardiac Progenitor Cell Differentiation

作者：Pagliari Stefania; Vilela Silva Ana Cristina; Forte Giancarlo; Pagliari Francesca; Mandoli Corrado; Vozzi Giovanni; Pietronave Stefano; Prat Maria; Licoccia Silvia; Ahluwalia Arti; Traversa Enrico^*; Minieri Marilena; Di Nardo Paolo

来源：Advanced Materials, 2011, 23(4): 514-+.

DOI：10.1002/adma.201003479

• 3-D scaffolds
• Biological signals
• Cardiac progenitors
• Cardiac stem cells
• Cardiac tissue engineering
• Mechanical signals
• Physical features
• Poly lactic acid

Three-dimensional cardiac tissue-specific scaffolds made of polylactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.

• 出版日期2011-1-25