Antibacterial constituents from Antarctic fungus, Aspergillus sydowii SP-1

作者：Li, Wen-ting; Luo, Dan; Huang, Jia-ning; Wang, Lin-lin; Zhang, Feng-guo; Xi, Tao; Liao, Jian-min^*; Lu, Yuan-yuan^*

来源：Natural Product Research, 2018, 32(6): 662-667.

DOI：10.1080/14786419.2017.1335730

• Aspergillus sydowii
• antibacterial activities
• MRSA
• MRSE
• alkaloid

One new alkaloid, named as acremolin C (1), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo-(L-Trp-L-Phe) (2), 4-hydroxyphenylacetic acid (3), (7S)-(+)-hydroxysydonic acid (4) and (7S, 11S)-(+)-12-hydroxysydonic acid (5), were isolated and identified. Biological studies disclosed that compounds 2, 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE.

• 出版日期2018
• 单位中国药科大学