A mathematical model for the interpretation of nuclear bomb test derived C-14 incorporation in biological systems

作者：Bernard Samuel; Frisen Jonas; Spalding Kirsty L^*

来源：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , 2010, 268(7-8): 1295-1298.

DOI：10.1016/j.nimb.2009.10.156

• C-14
• Bomb pulse
• Cell turnover
• Tissue maintenance
• Fat mass
• Adipocyte

Human tissues continually replace dying cells with newborn cells. However, the rate of renewal varies by orders of magnitudes between blood cells, which are renewed every day and neurons, for which renewal is non-existent or limited to specific regions of the brain. Between those extreme are many tissues that turnover on a time scale of years, although no direct measurements have been done. We present here a mathematical method to estimate cell turnover in slowly renewing biological systems. Age distribution of DNA can be estimated from the integration of radiocarbon derived from nuclear bomb-testing during the cold war (1955-1963). For slowly renewing tissues, this method provides a better estimate of the average age of the tissue than direct estimates from the bomb-curve. Moreover, death, birth and turnover rates can be estimated. We highlight this method with data from human fat cells.

• 出版日期2010-4