Understanding the host-pathogen interaction saves lives: lessons from vaccines and vaccinations

作者：Garon Julie R; Orenstein Walter A^*

来源：Current Opinion in Immunology, 2015, 36: 8-13.

DOI：10.1016/j.coi.2015.04.003

Vaccines are one of the most successful and cost-effective public health tools employed to date, yet these benefits are only realized when the life-saving intervention reaches each and every targeted individual. Vaccine development is prioritized based on a number of factors such as health burden, feasibility, and determination of potential target populations. But only through an arduous process of pre-clinical development and progressive clinical trials does a vaccine become licensed and recommended for use. Once used in a wider and more diverse population safety issues, long-term impact and other unintended outcomes may become apparent, influencing policy modification. This commentary explores the role host pathogen interaction plays in vaccine development and the operational and policy considerations that may impact vaccine success post-licensure.

• 出版日期2015-10