A sensitive and selective fluorescent probe for detection of glutathione in the presence of Cu2+ and its application to biological imaging

作者：Hu, Zhi-Qiang^*; Sun, Lei-Li; Gu, Ying-Ying; Jiang, Yi

来源：Sensors and Actuators B: Chemical , 2015, 212: 220-224.

DOI：10.1016/j.snb.2015.01.084

• Glutathione
• Fluorescence intensity change
• The detect limit
• Intracellular fluorescent imaging

A selective and sensitive method to detect glutathione (GSH) based on the complex of a coumarin-based probe and Cu2+ is reported. In response to GSH, the system provides remarkable fluorescence intensity change with the color change from colorless to yellow, and the detect limit is determined to be 3.6 x 10(-7)M. The background amino acids show small or no interference on the detection of GSH. Moreover, this probe could be applied to detect GSH via intracellular fluorescent imaging.

• 出版日期2015-6
• 单位青岛科技大学