Antihistamines are superior to topical steroids in managing Human Immunodeficiency Virus (HIV)-associated papular pruritic eruption

作者：Navarini Alexander A^*; Stoeckle Marcel; Navarini Susanne; Mossdorf Erik; Jullu Boniphace S; Mchomvu Rehema; Mbata Marco; Kibatala Patience; Tanner Marcel; Hatz Christoph; Schmid Grendelmeier Peter

来源：International Journal of Dermatology, 2010, 49(1): 83-86.

DOI：10.1111/j.1365-4632.2009.04279.x

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

• 出版日期2010-1