Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review

作者：Tu Yi An; Chen Yu Li; Lin Ming Chieh; Chen Chi An; Cheng Wen Fang^*

来源：Taiwanese Journal of Obstetrics & Gynecology, 2018, 57(1): 144-149.

DOI：10.1016/j.tjog.2017.12.025

• Neuroendocrine carcinoma
• Endometrium
• Chemotherapy
• Radiotherapy

Objective: To report a case and review published cases of large cell neuroendocrine carcinoma (LCNEC) of the endometrium.
Case report: A 51-year-old female presented with postmenopausal bleeding and a palpable pelvic mass. An endometrial biopsy showed a malignant mixed Mullerian tumor (MMMT). Suboptimal debulking surgery was performed. The final pathology revealed stage IVB endometrial LCNEC. Post-operative adjuvant chemotherapy with cisplatin and etoposide was administered. Two months after discontinuing adjuvant chemotherapy, salvage chemotherapy with cisplatin and ifosfamide was administered due to tumor progression; however, obstructive ileus was noted 2 months later. A segmental small bowel resection and palliative colostomy were performed. She died secondary to a post-operative infection 8 days after the operation.
Conclusion: Endometrial LCNEC is a rare but aggressive disease. If diagnosed, combined therapies, including staging surgery, following by adjuvant radiotherapy and chemotherapy, should be performed.

• 出版日期2018-2