A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging solution and in vivo studies of Ga-67-labeled species

作者：Chaves Silvia; Mendonca Ana C; Marques Sergio M; Isabel Prata M; Santos Ana C; Martins Andre F; Geraldes Carlos F G C; Amelia Santos M

来源：Journal of Inorganic Biochemistry, 2011, 105(1): 31-38.

DOI：10.1016/j.jinorgbio.2010.09.012

• Hydroxypyridinones
• Tripodal chelators
• Gallium radioisotope
• Biodistribution
• Gamma scintigraphy
• Gallium 67

The gallium(III) complex of a new tripodal 3 hydroxy 4-pyridinone (3 4-HP) chelator has been studied in terms of its physico-chemical and in vivo properties aimed at potential application as probe for nuclear imaging In particular based on spectrophotometric titrations the hexa-coordinated (1 1) gallium complex appeared as the major species in a wide physiological acid neutral pH range and its high stability (pGa = 27 5) should avoid drug-induced toxicity resulting from Ga(III) accumulation in tissues due to processes of transmetallation with endogenenous ligands or demetallation A multinuclear (H-1 and Ga-71) NMR study gave some insights into the structure and dynamics of the gallium(III) chelate in solution which are consistent with the tris-(3 4-HP) coordination and an eventual pseudo octahedral geometry Biodistribution and scintigraphic studies of the Ga-67(III) labelled chelate performed in Wistar rats confirmed the in vivo stability of the radiolabelled complex its non interaction with blood proteins a

• 出版日期2011-1