Phytochemical Studies of the Phenolic Substances in Aster glehni Extract and its Sedative and Anticonvulsant Activity

作者：Nugroho Agung; Kim Myung Hoe; Choi Jongwon; Choi Jae Sue; Jung Won Tae; Lee Kyung Tae; Park Hee Juhn^*

来源：Archives of Pharmacal Research, 2012, 35(3): 423-430.

DOI：10.1007/s12272-012-0304-7

• Aster glehni
• Compositae
• Caffeoylquinic acid
• Sedative
• Anticonvulsant
• Peroxynitrite
• High performance liquid chromatography

On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-O-p-coumaroylquinic acid (46.10 +/- 4.22 mg/g of dried weight) among CQs tested. The IC50 of the water-ethanol (7:3) extract was 4.23 +/- 0.24 mu g/mL in the peroxynitrite (ONOO-)-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite-scavenging mechanism.

• 出版日期2012-3