Antihyperglycemic Effect of Syringaldehyde in Streptozotocin-Induced Diabetic Rats

作者：Huang Chia Hsin; Chen Mei Fen; Chung Hsien Hui; Cheng Juei Tang^*

来源：Journal of Natural Products, 2012, 75(8): 1465-1468.

DOI：10.1021/np3003723

The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.

• 出版日期2012-8
• 单位河北医科大学