科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Over-expression of tumor-associated antigens (TAAs) may trigger secretion of their auto-antibodies. The present work was designed to test whether circulating antibody to P16 protein-derived antigens was altered in cervical cancer. @@@ Methods: 141 cases of cervical cancer patients, 133 cases of cervical benign tumor patients, and 153 healthy volunteers matched in age were recruited. The level of circulating P16 auto-antibody was tested using an ELISA developed in-house with linear peptide antigens derived from the P16 protein. @@@ Results: The P16 auto-antibody in the malignant tumor group had a significantly higher level than the healthy control group and the benign tumor group (t = 4.016, p < 0.001; t = 3.879, p < 0.001). Patients with stage I cervical cancer have the highest level of P16 autoantibody and the sensitivity against > 90% specificity was 20.3%. @@@ Conclusions: The circulating auto-antibody to P16 may be one of a series of potential biomarkers with early prognostic values for cervical cancer.
- 出版日期2016
- 单位吉林省肿瘤医院; 吉林大学
