Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students

作者：Silva Constanza P; Flores Sergio V^*

来源：Revista Medica de Chile, 2015, 143(6): 707-715.

• Alcohol Dehydrogenase
• Alcohol Drinking
• Aldehyde Dehydrogenase
• Genetics, Population
• Genetic Variation

Background: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively. Aim: To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material and Methods: Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old. Results: No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns-not included in the AUDIT questionnaire-were identified. Conclusions: No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.

• 出版日期2015-6